Erection problems

Davis says polyketals have an advantage over other biodegradable polymers, in that they break down into neutral, excretable compounds that aren’t themselves inflammatory. Polyesters such as PLGA (polylactic-co-glycolic acid) are approved for use in sutures and grafts. However, when they are made into particles small enough to be broken down in the body, polyesters cause inflammation – exactly what the cheap norvasc are supposed to stop, he says. When the particles were injected into rats’ hearts, the researchers could see an inhibition of the MAP kinase enzyme lasting for a week. However, the effect on heart function was greater after 21 days. Davis says this result suggests that the main way the particles helped the heart was to prevent the scarring that sets in after the initial tissue damage of a heart attack. He and Murthy are exploring polyketal particles as delivery vehicles for drugs or proteins in several organs: heart, liver, lungs and spinal cord. The research was funded by EmTech Bio, the National Science Foundation, the National Institutes of Health, the Department of Homeland Security and a seed grant from Johnson & Johnson.